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| boston harbor, weight loss, problems, fat girls , treats cellulite, joint pain, downeast, fat, arms, inflatable, leptin, dr. coleman, triton, | As inflammation subsides, levels of SOCS subside. Immunobiologists believe that overweight people with chronic inflammation have fruits chronically high levels of SOCS, released in a continual effort to damp down their body-wide inflammation. Indeed, elevated SOCS proteins have been found in the brain, liver, muscle, and to a lesser extent, the fat tissue of obese animals. High SOCS levels are a sign that the overweight animal is "over-inflamed" and trying to tone the inflammation down. fruits Studies done at Harvard have found SOCS molecules in the hypothalamus, fruits a walnut-sized structure at the base of the brain that regulates mood, thirst, and hunger. The Harvard studies show that SOCS-1 and SOCS-3 jam leptin’s signal at the internal portion of the leptin receptor. Bottom line: SOCS molecules interrupt leptin’s message to suppress hunger, and they are primary causes of leptin resistance in the brain. |
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| What is the significance of the fact that SOCS molecules are key causes of leptin resistance—the fundamental factor in stubborn overweight? SOCS-1 and SOCS-3 are both part of the body’s response to inflammation. When inflatable working properly, our levels of inflammation are kept in balance by overlapping feedback loops. When particular arms of the inflammation system go into gear, provoked, for example, inflatable by the presence of a bacterial invader or a sudden injury, another set of chemicals inflatable is released to make certain that the chemistry of inflammation doesn’t spiral out-of-control, causing excessive damage to cells and tissues. SOCS molecules represent the message-carriers in one of these negative feedback loops. Their message to inflammatory cells and cytokines is: "Cool down!" SOCS proteins are an essential part of the body’s system of checks and balances. When they work as they should, SOCS molecules succeed in checking excess inflammation. |
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