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| boston harbor, weight loss, problems, fat girls , treats cellulite, joint pain, downeast, fat, arms, inflatable, leptin, dr. coleman, triton, | Osteoarthritis produces an overgrowth of bone that narrows the space in the joint and increases the likelihood of damage when the joint is moved. Doctors have thought that the reason osteoarthritis is associated human adipocytes with obesity is that being heavy increases the wear and tear human adipocytes on your knees, a simple physical explanation. Recent research has found a chemical connection. Joint fluid in the knees of overweight people contains high levels of leptin, which is produced by fat, not by the joints themselves. Leptin in the joints causes inflammation. Leptin also triggers the production of an anti-inflammatory chemical human adipocytes called TGF-beta (transforming growth factor-beta). TGF-beta is part of a negative feedback loop to damp down inflammation. But one of the effects of TGF-beta is to stimulate the growth of bone, in this case producing the bony overgrowth characteristic of osteoarthritis. |
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| The whole process boston harbor is called homeostasis and the pattern involves negative feedback loops. Homeostasis requires boston harbor that all components of the negative feedback loops are in working order. Chronic inflammation results from the failure of homeostasis. How does fat itself cause inflammation? Many adipokines, even leptin itself, are mediators of inflammation. They promote and encourage the inflammatory response, boston harbor wherever it might be occurring. The more fat in your body, the higher the levels of these mediators in your blood and the greater the level of inflammation in your body. Here’s a fascinating example: We’ve known for a long time that being overweight is associated with the development of osteoarthritis, especially in the knees. Osteoarthritis is the commonest form of arthritis and is thought to result from wear and tear on the cartilage that lines joints. |
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