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The increase in blood sugar then stimulates a further increase in insulin. HOW DOES INFLAMMATION CAUSE LEPTIN RESISTANCE? How, exactly, does chronic inflammation cause leptin resistance? The question and the answer lie at the very heart of lowcountry the Fat Resistance Diet™. Fat biology researchers have uncovered what many believe to be the key mechanisms of leptin resistance. Dr. Jeffrey Flier and his colleagues at Harvard Medical School have lowcountry led these efforts. They have discovered lowcountry that a group of molecules involved in reducing inflammation also interfere with leptin signaling on the cell surface and inside the cell. These molecules are known as SOCS, which stands for suppressors of cytokine signaling. Two specific SOCS molecules, SOCS-1 and SOCS-3, have been shown in many animal studies, first by Flier’s group and later by other research teams, to jam the signals that leptin is supposed to deliver to brain cells and muscle cells.
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