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Experimental Design Patients diagnosed with OA by a physician pinoy were matched for body mass, age, gender, and OA history and randomly assigned to 1 of 2 topical treatment groups in a pinoy double-blind manner receiving either: 1) a cream consisting of a blend of cetylated fatty acids (CFA); or 2) a placebo (P) cream. Patients were tested for functional performance on 3 occasions: pinoy 1) prior to treatment (T1), 2) 30 min after patients' first treatment with a cream to measure the initial response, and 3) after a 30-day topical cream treatment period. Patients were instructed to apply a standardized amount of cream to both knees. The topical cream was applied to the anterior, posterior, and lateral aspects of both knees over a 10-12 cm area twice per day (at a standardized morning and evening time point) for 30 days. In addition, each patient maintained his/her current food and beverage intake throughout the 30-day period via 3-day diet records and nutritional counseling.
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