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Increases the breakdown of lipids and speeds the removal of VLDL from the bloodstream and may decrease VLDL production by the liver High VLDL cholesterol Low HDL cholesterol Dysbetalipoproteinemia Diarrhea, foods nausea, bloating, abdominal pain, rash, abnormal levels of liver enzymes, muscle inflammation, and gallstones Lipoprotein synthesis inhibitors Niacin Decreases the production rate of VLDL, which is used to synthesize LDL High LDL and VLDL cholesterol and low HDL cholesterol Dysbetalipoproteinemia foods Flushing, itching, digestive upset, ulcers, increased levels of liver enzymes, gout, and a high blood sugar level (hyperglycemia) Statins (HMG-CoA reductase inhibitors) Atorvastatin Fluvastatin Lovastatin Pravastatin foods Simvastatin Blocks the synthesis of cholesterol, increasing the removal of LDL from the bloodstream High LDL cholesterol Combined hyperlipidemia Mild constipation, loose stools, bloating, headaches, rashes, fatigue, and, rarely, increased levels of liver enzymes, muscle aches due to inflammation (myositis) and muscle degeneration (rhabdomyolysis) HMG-CoA = 3-hydroxy-3-methylglutaryl coenzyme A.
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